USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: 1433E_HUMAN USC-OGP 2-DE database:  1433E_HUMAN 1433E_HUMAN General information about the entry View entry in simple text format Entry name 1433E_HUMAN Primary accession number P62258 Secondary accession number(s) P42655 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=14-3-3 protein epsilon; Short=14-3-3E;. Gene name Name=YWHAE Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0153: pI=4.62; Mw=30348 Cross-references UniProtKB/Swiss-Prot P62258; 1433E_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name 1433E_HUMAN Primary accession number P62258 Secondary accession number(s) B3KY71 D3DTH5 P29360 P42655 Q4VJB6 Q53XZ5 Q63631 Q7M4R4 Sequence was last modified on  July 5, 2004 (version 1) Annotations were last modified on  March 15, 2017 (version 153) Name and origin of the protein Description RecName: Full=14-3-3 protein epsilon; Short=14-3-3E; Gene name Name=YWHAE Encoded on Name=YWHAE Keywords 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Nucleus; Phosphoprotein; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U20972; AAC50175.1; -; mRNA EMBL U54778; AAC50710.1; -; mRNA EMBL U43399; AAC50625.1; -; mRNA EMBL U43430; AAD00026.1; -; mRNA EMBL U28936; AAA75301.1; -; mRNA EMBL AB017103; BAA32538.1; -; Genomic_DNA EMBL AY883089; AAX68683.1; -; mRNA EMBL AK128785; BAG54733.1; -; mRNA EMBL AK295260; BAG58249.1; -; mRNA EMBL AK316185; BAH14556.1; -; mRNA EMBL BT007161; AAP35825.1; -; mRNA EMBL CH471108; EAW90628.1; -; Genomic_DNA EMBL CH471108; EAW90629.1; -; Genomic_DNA EMBL BC000179; AAH00179.1; -; mRNA EMBL BC001440; AAH01440.1; -; mRNA CCDS CCDS11001.1; -. [P62258-1]; . PIR A61235; A61235; . PIR I38947; I38947; . RefSeq NP_006752.1; NM_006761.4. [P62258-1]; . UniGene Hs.513851; -; . PDB 2BR9; X-ray; 1.75 A; A=1-233 PDB 3UAL; X-ray; 1.80 A; A=1-232 PDB 3UBW; X-ray; 1.90 A; A=1-234 PDBsum 2BR9; -; . PDBsum 3UAL; -; . PDBsum 3UBW; -; . ProteinModelPortal P62258; -; . SMR P62258; -; . BioGrid 113363; 390; . DIP DIP-36676N; -; . IntAct P62258; 174; . MINT MINT-4998623; -; . STRING 9606.ENSP00000264335; -; . ChEMBL CHEMBL3329082; -; . DrugBank DB01780; Fusicoccin; . iPTMnet P62258; -; . PhosphoSitePlus P62258; -; . SwissPalm P62258; -; . BioMuta YWHAE; -; . DMDM 51702210; -; . OGP P42655; -; . UCD-2DPAGE P62258; -; . EPD P62258; -; . PaxDb P62258; -; . PeptideAtlas P62258; -; . PRIDE P62258; -; . TopDownProteomics P62258-1; -. [P62258-1]; . DNASU 7531; -; . Ensembl ENST00000264335; ENSP00000264335; ENSG00000108953. [P62258-1]; . Ensembl ENST00000571732; ENSP00000461762; ENSG00000108953. [P62258-2]; . Ensembl ENST00000616643; ENSP00000481059; ENSG00000274474. [P62258-2]; . Ensembl ENST00000627231; ENSP00000487356; ENSG00000274474. [P62258-1]; . GeneID 7531; -; . KEGG hsa:7531; -; . UCSC uc002fsk.4; human. [P62258-1]; . CTD 7531; -; . DisGeNET 7531; -; . GeneCards YWHAE; -; . H-InvDB HIX0013751; -; . H-InvDB HIX0030006; -; . HGNC HGNC:12851; YWHAE; . HPA CAB016200; -; . HPA CAB021109; -; . HPA CAB047350; -; . HPA HPA008445; -; . MalaCards YWHAE; -; . MIM 605066; gene; . neXtProt NX_P62258; -; . OpenTargets ENSG00000108953; -; . Orphanet 217385; 17p13.3 microduplication syndrome; . Orphanet 261257; Distal 17p13.3 microdeletion syndrome; . Orphanet 531; Miller-Dieker syndrome; . PharmGKB PA37440; -; . eggNOG KOG0841; Eukaryota; . eggNOG COG5040; LUCA; . GeneTree ENSGT00760000119116; -; . HOVERGEN HBG050423; -; . InParanoid P62258; -; . KO K06630; -; . OMA KESALIM; -; . OrthoDB EOG091G0VKY; -; . PhylomeDB P62258; -; . TreeFam TF102003; -; . Reactome R-HSA-111447; Activation of BAD and translocation to mitochondria; . Reactome R-HSA-1445148; Translocation of GLUT4 to the plasma membrane; . Reactome R-HSA-2028269; Signaling by Hippo; . Reactome R-HSA-205025; NADE modulates death signalling; . Reactome R-HSA-2565942; Regulation of PLK1 Activity at G2/M Transition; . Reactome R-HSA-3371453; Regulation of HSF1-mediated heat shock response; . Reactome R-HSA-3371511; HSF1 activation; . Reactome R-HSA-380259; Loss of Nlp from mitotic centrosomes; . Reactome R-HSA-380270; Recruitment of mitotic centrosome proteins and complexes; . Reactome R-HSA-380284; Loss of proteins required for interphase microtubule organization from the centrosome; . Reactome R-HSA-5620912; Anchoring of the basal body to the plasma membrane; . Reactome R-HSA-5625740; RHO GTPases activate PKNs; . Reactome R-HSA-5628897; TP53 Regulates Metabolic Genes; . Reactome R-HSA-75035; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; . Reactome R-HSA-8854518; AURKA Activation by TPX2; . Reactome R-HSA-8862803; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; . Reactome R-HSA-8876198; RAB GEFs exchange GTP for GDP on RABs; . SignaLink P62258; -; . SIGNOR P62258; -; . ChiTaRS YWHAE; human; . EvolutionaryTrace P62258; -; . GeneWiki YWHAE; -; . GenomeRNAi 7531; -; . PMAP-CutDB P62258; -; . PRO PR:P62258; -; . Proteomes UP000005640; Chromosome 17; . Bgee ENSG00000108953; -; . CleanEx HS_YWHAE; -; . ExpressionAtlas P62258; baseline and differential; . Genevisible P62258; HS; . GO GO:0030424; C:axon; IEA:Ensembl; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0005871; C:kinesin complex; IEA:Ensembl; . GO GO:0042470; C:melanosome; IEA:UniProtKB-SubCell; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005739; C:mitochondrion; IEA:Ensembl; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0019899; F:enzyme binding; IPI:UniProtKB; . GO GO:0042826; F:histone deacetylase binding; IPI:BHF-UCL; . GO GO:0044325; F:ion channel binding; IPI:BHF-UCL; . GO GO:0023026; F:MHC class II protein complex binding; IDA:UniProtKB; . GO GO:0051219; F:phosphoprotein binding; IPI:BHF-UCL; . GO GO:0050815; F:phosphoserine binding; IPI:BHF-UCL; . GO GO:0015459; F:potassium channel regulator activity; IDA:BHF-UCL; . GO GO:0046982; F:protein heterodimerization activity; IPI:BHF-UCL; . GO GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; TAS:Reactome; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL; . GO GO:0034605; P:cellular response to heat; IDA:UniProtKB; . GO GO:0021987; P:cerebral cortex development; IEA:Ensembl; . GO GO:0097711; P:ciliary basal body docking; TAS:Reactome; . GO GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0035329; P:hippo signaling; TAS:Reactome; . GO GO:0021766; P:hippocampus development; IEA:Ensembl; . GO GO:0035556; P:intracellular signal transduction; TAS:ProtInc; . GO GO:0000165; P:MAPK cascade; IDA:UniProtKB; . GO GO:0061024; P:membrane organization; TAS:Reactome; . GO GO:0086013; P:membrane repolarization during cardiac muscle cell action potential; IC:BHF-UCL; . GO GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:Reactome; . GO GO:1902309; P:negative regulation of peptidyl-serine dephosphorylation; IDA:BHF-UCL; . GO GO:0001764; P:neuron migration; IEA:Ensembl; . GO GO:0046827; P:positive regulation of protein export from nucleus; IDA:UniProtKB; . GO GO:1900740; P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; TAS:Reactome; . GO GO:0006605; P:protein targeting; IEA:Ensembl; . GO GO:1900034; P:regulation of cellular response to heat; TAS:Reactome; . GO GO:0086091; P:regulation of heart rate by cardiac conduction; IC:BHF-UCL; . GO GO:0003064; P:regulation of heart rate by hormone; NAS:BHF-UCL; . GO GO:0060306; P:regulation of membrane repolarization; IDA:BHF-UCL; . GO GO:1901016; P:regulation of potassium ion transmembrane transporter activity; IDA:BHF-UCL; . GO GO:0021762; P:substantia nigra development; IEP:UniProtKB; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . Gene3D 1.20.190.20; -; 1; . InterPro IPR000308; 14-3-3; . InterPro IPR023409; 14-3-3_CS; . InterPro IPR023410; 14-3-3_domain; . PANTHER PTHR18860; PTHR18860; 1; . Pfam PF00244; 14-3-3; 1; . PIRSF PIRSF000868; 14-3-3; 1; . PRINTS PR00305; 1433ZETA; . SMART SM00101; 14_3_3; 1; . SUPFAM SSF48445; SSF48445; 1; . PROSITE PS00796; 1433_1; 1; . PROSITE PS00797; 1433_2; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

[Home]